Sorry if all these bug reports are getting you down, Orkin.

We still love you. :*
Anyway, I'm getting random lockups when using pure 32-bit textures in combination with 2xSaI. I have, however, found one that is completely repeateable, in both 1964 and Mupen:
Set Texture Bit Depth to 32-bit only, and enable 2xSaI. Start Super Smash Brothers. Do a standard single player game, choose Link. You'll see the briefing screen and hear the announcer say "Link vs. Link". Then... nothing. The game locks up.
And another one that doesn't seem to be affected by 2xSaI setting, or emulator. Do single player as Link and get up to the "break the targets" level, level 4, IIRC. Play for a few seconds and it freezes.