Windows needs serious fixing of the Xbox 360 controller. Keys don't map properly, and there's no rumble feature. Being a console emulator, this is a critical feature.
yes, the mapping problem is documented at https://github.com/mupen64plus/mupen64plus-ui-python/issues/2
The rumble feature works fine for me. You just have to tell the emulator through your "rumble" key (right bottom of the input configuration screen) that you now switched the addon module of the virtual controller to the rumblepak.
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And just to remember everyone: This frontend is developed by volunteers like you.
Which essentially means: If you say "xyz has not been fixed" then it actually means "I haven't fixed xyz yet". If you want to fix it then please submit patches or contribute helpful to get it resolved.