Relatively simple? No.
SnowBro wrote a program called Hexposure that is a normal hex editor with the ability to search for text in a ROM based on bytes of relative values; not just ANSI text. So things like 00 0A 10 could be the text "0AG" as opposed to the ANSI version of 30 41 47.
Many GBA ROMs have compression on the tilesets for text, however, so changing those to regional characters may not be possible.
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Your best bet is to disassemble the ROM itself, change what you want, then recompile it into a whole new ROM that uses the same programming... and that is anything but simple.