Dunno, I always have the OS and all the programs that it needs in the primary partition. However games are considered programs as well, and I always have them in another partition, mainly because they are getting heavier these days, and I haven't seen any special boost in them. Just be sure that you OS partition and the one that keeps the programs has a moderate free space and defragment it frequently, with that, you'll be fine. Defragment all the other partitions as well.