Maybe because I`m a low end PC user, but the fastest configuration possible for me is:
1964 0.8.5 emu + Glide64 + UltraHle audio plugin + Blaze input plugin
(for my voodoo banshee card)
or
1964 0.8.5 emu + JaboD3D 1.5 + UltraHle audio plugin + Blaze input plugin