http://www.rxnes.com/ has had a notable interesting change in its current release, heres what the readme says:

- Added : Wiimote Controls! ( Autodetects 1 Wiimote [Player 1] Bluetooth) Up to 4 Players coming soon, I only have 1 wiimote ATM.
Hold 1 & 2 on wiimote and pair in windows bluetooth pairing, it will be autodetected. (On next start.)
- Fixed Z,X to be B,A instead of A,B.


Nice to have that support built in for wiimotes, and continues to expand on its features.

You can download at http://www.rxnes.com/