Can't play games

[BioTube]

When I load up a ROM, it goes straight to the music screen. If I go to the 'play' option, it goes to a blank screen and freezes. I know these ROMs work since I've played them in nullDC. However, one of them makes a load clicking noise almost as soon as the game begins and cuts out all sound. I want to see if it's the ROM or if it's doing something that screws up the nullDC sound system(Makaron is out of the question since I don't have a gamepad).

[M-a-v-e-r-i-c]

Can I get some support on this issue too? Nothing is working all of a sudden.