These are the ini setting's im using for Donkey kong 64 (u) as the pre-set does not work on my system.
Maybe this will help in some way.
[EC58EABF-AD7C7169-C:45]
Game Name=DONKEY KONG 64
Comments=Playable!
Alternate Title=Donkey Kong 64 (U) [!]
Check Self-modifying Code=8
Emulator=1
RDRAM Size=2
Max FPS=4
Save Type=6
TLB=1
EEPROM Size=2
Counter Factor=3
Use Register Caching=1
FPU Hack=1
DMA=1
Link 4KB Blocks=1
Advanced Block Analysis=1
Assume 32bit=2
HLE=2
RSP_RDP_Timing=2
CFB_RW=2
NumberOfPlayers=1
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4real