I think this is a issue of the emulator, in the known issues it has
Resident Evil 2
* depth/sprite depth problems in some games
Some games have problems where sprites show through things that should block them. Sometimes using D3D transformation pipeline helps, but in many cases there is no fix for this other than using a 3rd party video plugin.
* games with audio problems (MuysX)
The following games use MusyX audio compression technology and are known to have issues - typically samples sound very garbled/glitchy/unpleasant or are missing, whilst other components of sound (e.g. background music) may be unaffected. We believe this is due to timing being innacurate in the core.
There is no fix for these issues other than using a 3rd party audio plugin with its own sync method, OR using a different emulator (core).
It is problem that you refiering to, what is you computer spec and the plugin you using. also the other game known issue is
here . I remove some reducted info that wasn't related.